A diverse and distinct microbiome inside living trees
A diverse and distinct microbiome inside living trees Summary This Nature paper (Arnold et al., 2025) maps the microbial communities living inside the wood of living trees. Sampling across 16…
Excised DNA circles from V(D)J recombination promote relapsed leukaemia
Excised DNA circles from V(D)J recombination promote relapsed leukaemia Key Points • Excised signal circles (ESCs) — extrachromosomal circular DNAs created by V(D)J recombination — replicate and persist through many…
Structural basis of fast N-type inactivation in Kv channels
Summary The authors used cryo-electron microscopy, mass spectrometry and electrophysiology to define how the N terminus of the Shaker Kv channel mediates fast N-type inactivation. High-resolution cryo-EM maps (2.67–3.05 Å…
High-accuracy laser spectroscopy of
$${{\bf{H}}}_{{\bf{2}}}^{{\boldsymbol{+}}}$$
and the proton–electron mass ratio
High-accuracy laser spectroscopy of H2+ and the proton–electron mass ratio Summary This paper reports Doppler-free, high-accuracy laser spectroscopy of a rovibrational vibrational overtone of the homonuclear molecular ion H2+. Using…
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers Summary This Nature paper reports discovery and preclinical characterisation of selective small-molecule inhibitors of the histone methyltransferase NSD2 (notably IACS-17596…
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
Summary This Nature paper reports that microglia — the brain’s resident immune cells — actively support the production of GABAergic interneurons in the developing human medial ganglionic eminence (hMGE) by…
In situ light-field imaging of octopus locomotion reveals simplified control
In situ light-field imaging of octopus locomotion reveals simplified control Summary Researchers deployed a remotely operated vehicle (ROV) equipped with a light-field imaging system called EyeRIS plus an ultra-high-definition science…
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis Summary This Nature paper reports that small RNAs bearing N-linked glycans (“glycoRNAs”) reside on cell surfaces and in circulation, and that those…
Novel assembly of a head–trunk interface in the sister group of jawed vertebrates
Novel assembly of a head–trunk interface in the sister group of jawed vertebrates Summary This Nature paper (Miyashita et al., 2025) presents high-resolution, non‑destructive synchrotron X‑ray microtomography of the Devonian…
Whole-genome sequencing of 490,640 UK Biobank participants
Whole-genome sequencing of 490,640 UK Biobank participants Summary The UK Biobank has completed deep whole-genome sequencing (WGS) for 490,640 participants (mean coverage 32.5×), producing a resource that identifies ~1.5 billion…