Summary The authors used cryo-electron microscopy, mass spectrometry and electrophysiology to define how fast N‑type inactivation occurs in the Shaker Kv channel. They show that an extended, predominantly non‑polar N‑terminal…
High-accuracy laser spectroscopy of H2+ and the proton–electron mass ratio Summary The authors report Doppler-free, high-accuracy laser spectroscopy of a vibrational electric-quadrupole (E2) transition in the homonuclear molecular ion H2+.…
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers Summary This Nature paper reports the discovery and preclinical characterisation of selective small-molecule inhibitors of the histone methyltransferase NSD2 (notably…
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 Summary This Nature paper reports that microglia in the prenatal human medial ganglionic eminence (hMGE) support prolonged production of GABAergic…
In situ light-field imaging of octopus locomotion reveals simplified control Summary This study used a novel light-field imaging system, EyeRIS, mounted on an ROV to record high-resolution, volumetric footage of…
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis Summary This Nature paper reports that small RNAs can be N-glycosylated (glycoRNAs) and that these attached N-glycans mask RNAs from innate immune…
Novel assembly of a head–trunk interface in the sister group of jawed vertebrates Summary This Nature paper presents a high-resolution, non-destructive synchrotron X-ray microtomography reconstruction of the Devonian osteostracan Norselaspis…
Whole-genome sequencing of 490,640 UK Biobank participants Summary The UK Biobank completed high-coverage whole-genome sequencing (WGS) for 490,640 participants (mean coverage 32.5×), producing a deeply phenotyped, population-scale resource. The WGS…
Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis Summary This Nature study describes a previously unknown, homeostatic communication pathway between microglia and neurons centred on ganglioside GM2 turnover. Using unbiased lipidomics,…
Inconclusive proof of ferroelectricity in peptide-VDF ribbons Summary This Matters Arising (Litterst, Butkevich & Kemerink) challenges the claim by Yang et al. that vinylidene fluoride (VDF) oligomers paired with tetrapeptides…
