A diverse and distinct microbiome inside living trees
A diverse and distinct microbiome inside living trees Summary This Nature paper reports a broad survey of the internal microbiome of living trees, showing that wood hosts a large, specialised…
Excised DNA circles from V(D)J recombination promote relapsed leukaemia
Excised DNA circles from V(D)J recombination promote relapsed leukaemia Summary This Nature study shows that excised signal joint circles (ESCs) produced during V(D)J recombination are not inert by-products but replicate,…
Structural basis of fast N-type inactivation in Kv channels
Structural basis of fast N-type inactivation in Kv channels Summary This paper presents high-resolution cryo-EM structures, mass-spectrometry and electrophysiology that reveal how the N terminus of the Shaker Kv channel…
High-accuracy laser spectroscopy of
$${{\bf{H}}}_{{\bf{2}}}^{{\boldsymbol{+}}}$$
and the proton–electron mass ratio
High-accuracy laser spectroscopy of H2+ and the proton–electron mass ratio Summary This paper reports Doppler-free electric-quadrupole (E2) laser spectroscopy of a vibrational overtone in the homonuclear molecular ion H2+ with…
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers Summary This Nature paper describes the discovery and preclinical characterisation of selective small-molecule inhibitors of NSD2 (notably IACS-17596 and IACS-17817).…
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 Key points • Microglia concentrate in the inner and outer subventricular zones (iSVZ/oSVZ) of the human medial ganglionic eminence (hMGE)…
In situ light-field imaging of octopus locomotion reveals simplified control
In situ light-field imaging of octopus locomotion reveals simplified control Summary Researchers deployed a novel light-field imaging system (EyeRIS) mounted to an ROV at the 3,000 m-deep ‘‘Octopus Garden’’ to…
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis Summary This Nature study shows that small RNAs bearing N-linked glycans (glycoRNAs) are masked from the innate immune system and that enzymatic…
Novel assembly of a head–trunk interface in the sister group of jawed vertebrates
Novel assembly of a head–trunk interface in the sister group of jawed vertebrates Summary This Nature paper presents high-resolution, non-destructive synchrotron X-ray microtomography of the Devonian osteostracan Norselaspis glacialis (specimen…
Whole-genome sequencing of 490,640 UK Biobank participants
Whole-genome sequencing of 490,640 UK Biobank participants Summary This Nature paper reports deep whole-genome sequencing (WGS) for 490,640 UK Biobank participants. The consortium generated high-quality variant calls (SNPs, indels and…