Genetic suppression features ABHD18 as a Barth syndrome therapeutic target Summary This Nature paper reports a multi-platform genetic and biochemical study that identifies ABHD18 — an α/β-hydrolase domain protein —…
Multiple overlapping binding sites determine transcription factor occupancy Summary This Nature paper introduces PADIT-seq, a high-throughput in vitro assay that measures transcription factor (TF) affinity to all possible 10-base-pair DNA…
Amygdala–liver signalling orchestrates glycaemic responses to stress Summary This Nature paper identifies a previously unrecognised neural axis from the medial amygdala (MeA) to the ventromedial hypothalamus (VMH) that rapidly drives…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary This paper presents spatial‑DMT, a new spatial multi‑omics method that simultaneously profiles the DNA methylome (mCG and mCH) and…
Summary This paper identifies a thalamic gate that integrates internal sexual drive and tactile contact to time the switch from appetitive to consummatory mating behaviours in male mice. The authors…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study combines droplet-based single-nucleus RNA-sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS, using PTA) and MERFISH spatial transcriptomics on human…
Analog optical computer for AI inference and combinatorial optimization Summary The paper introduces the Analog Optical Computer (AOC), an all-analog hybrid opto-electronic platform that runs iterative fixed-point searches to accelerate…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This Nature paper (Dey et al., 2025) combines phylogenetically informed sampling, live imaging, genetics and optogenetics to explain how different flies…
A brain-wide map of neural activity during complex behaviour Summary This Nature paper from the International Brain Laboratory (IBL) presents a publicly available, standardised, brain‑wide electrophysiological dataset recorded while mice…
A prudent planetary limit for geologic carbon storage Summary This Nature paper produces a spatially explicit, precautionary estimate of how much CO2 can reasonably be stored in sedimentary basins worldwide…
