One mother for two species via obligate cross-species cloning in ants Key Points • Messor ibericus queens produce hybrid workers that combine an M. ibericus maternal genome with an M.…
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target Summary This Nature paper uses genome-wide genetic suppression screens, biochemical analysis and in vivo models to identify ABHD18 (an α/β-hydrolase…
Multiple overlapping binding sites determine transcription factor occupancy Summary This Nature paper introduces PADIT-seq, a high-throughput in vitro method that assays transcription factor (TF) binding to all possible 10-base sequences.…
Amygdala–liver signalling orchestrates glycaemic responses to stress Summary This Nature paper identifies a medial amygdala (MeA) → ventromedial hypothalamus (VMH) → sympathetic → liver axis that rapidly mobilises glucose in…
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia Summary This Nature paper uses allele-specific open chromatin mapping (ASoC) in human iPSC-derived brain cells to prioritise functional non-coding Alzheimer’s…
Commensal yeast promotes Salmonella Typhimurium virulence Summary This Nature study shows that the common gut yeast Candida albicans can increase the virulence of Salmonella enterica serovar Typhimurium (STm). In mouse…
Supervised learning in DNA neural networks Summary This paper reports a DNA-based molecular system that performs supervised learning in vitro. Using extended seesaw DNA strand-displacement motifs, the authors engineered two…
3D-printed micro ion trap technology for quantum information applications Summary This Nature paper reports the design, fabrication and characterisation of micro ion traps made by high-resolution 3D printing (two-photon polymerisation)…
Adaptive and context-aware volumetric printing Summary This paper presents GRACE (Generative, Adaptive, Context-Aware 3D Printing), a workflow that combines tomographic volumetric printing with light-sheet imaging, computer vision and parametric modelling…
Training of physical neural networks Summary This Nature review surveys the state of physical neural networks (PNNs) — systems that use analogue physics (optical, electronic, mechanical, chemical and other substrates)…
