Patterned invagination prevents mechanical instability during gastrulation Summary This study shows that the prominent but transient cephalic furrow in dipteran embryos (notably Drosophila) plays a mechanical role during gastrulation: it…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary This Nature paper presents spatial-DMT, a spatial multi-omics method that simultaneously profiles the DNA methylome and transcriptome from the…
A circuit that integrates drive state and social contact to gate mating Summary This Nature paper identifies a neural gate that times the switch from appetitive to consummatory male mating…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study applies droplet-based single-nucleus RNA-sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and MERFISH spatial transcriptomics to human prefrontal cortex…
Analog optical computer for AI inference and combinatorial optimization Summary The paper introduces the analog optical computer (AOC), a hybrid opto-electronic platform that runs entirely in the analog domain to…
A brain-wide map of neural activity during complex behaviour Summary This Nature paper from the International Brain Laboratory presents a publicly available, standardised electrophysiological dataset that maps neural activity across…
A prudent planetary limit for geologic carbon storage Summary This Nature paper maps global sedimentary basins and applies a precautionary set of exclusion layers (protected areas, polar regions, seismic hazard,…
DNA2 enables growth by restricting recombination-restarted replication Summary This Nature paper shows that the conserved nuclease/helicase DNA2 is essential for cell proliferation because it prevents excessive homologous-recombination restarted replication (HoRReR)…
Two ants, two species, one mother Summary Iberian harvester ants have been observed producing offspring that belong to two distinct species from a single queen, and engineers have uncovered mechanisms…
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition Summary This Nature article reports that Cas9 performs a previously unrecognised role beyond its well-known RNA-guided nuclease activity: it senses…
