A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 Summary This paper reports the discovery and structural characterisation of a prefusion-specific nanobody (Nb1_gbHSV) that neutralises herpes simplex virus…
Brain-wide representations of prior information in mouse decision-making Summary This Nature study from the International Brain Laboratory asks where and how the brain represents prior information used during perceptual decisions.…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary This paper presents spatial-DMT, a spatial multi-omics method that simultaneously profiles the DNA methylome and the transcriptome from the…
A circuit that integrates drive state and social contact to gate mating Summary This paper identifies a thalamic circuit that gates the switch from appetitive to consummatory male mating behaviour…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study merges droplet-based single-nucleus RNA-seq (snRNA-seq; 367,317 nuclei), single-cell whole-genome sequencing (scWGS) and MERFISH spatial transcriptomics from fresh-frozen…
Analog optical computer for AI inference and combinatorial optimisation Summary The paper introduces the analog optical computer (AOC), a hybrid opto-electronic platform that runs entirely analogue fixed-point searches to accelerate…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This Nature paper examines how developing fly embryos avoid destructive mechanical collisions between expanding head and trunk tissues during gastrulation. The…
A brain-wide map of neural activity during complex behaviour Summary This paper from the International Brain Laboratory presents a publicly available, brain-wide electrophysiological dataset recorded with 699 Neuropixels probe insertions…
A prudent planetary limit for geologic carbon storage Summary This Nature paper produces a spatially explicit, precautionary estimate of how much CO2 can prudently be stored in sedimentary basins worldwide…
DNA2 enables growth by restricting recombination-restarted replication Summary This Nature paper shows that the conserved nuclease–helicase DNA2 is essential for cell proliferation because it prevents recombination-restarted replication (HoRReR) at stalled…
