Flu’s link to cardiovascular disease shows why vaccination is essential

Flu’s link to cardiovascular disease shows why vaccination is essential

Summary

Influenza is more than a short-lived respiratory illness: it can sharply raise the risk of acute cardiovascular events. Recent analyses show a marked increase in heart attacks and other cardiovascular complications in the period immediately after confirmed flu infection. The virus triggers strong inflammation, increases clotting risk and places extra strain on the heart — effects that can precipitate crises in vulnerable people. Vaccination and other preventive measures therefore act not only to stop respiratory illness but also to reduce cardiovascular deaths.

Key Points

  • Flu can provoke a powerful inflammatory response that raises heart rate, activates platelets and increases clotting risk.
  • A 2018 study found the risk of heart attack rises about sixfold in the week after a confirmed influenza infection.
  • Among adults hospitalised with influenza, nearly one in eight had an acute cardiovascular event.
  • About 4% of heart-attack deaths in people aged 50+ worldwide have been attributed to influenza — roughly 300,000 deaths potentially preventable.
  • Public-health messaging should present flu vaccination as a cardiovascular-protective measure, especially for people with existing heart disease.

Content summary

People often dismiss seasonal influenza as a brief nuisance, but evidence shows it can trigger severe cardiovascular events. Fever, dehydration and systemic inflammation combine to increase cardiac workload and promote clot formation. Large observational studies and hospital data link recent influenza infection to spikes in heart attacks, heart failure and sudden cardiac events. Framing vaccination purely as respiratory protection misses its broader benefit: preventing infections that can precipitate life-threatening cardiovascular complications.

The author argues for a shift in clinical practice and public-health communications. Clinicians should consider recent viral illness when assessing acute cardiac events, and vaccination campaigns should target those with cardiovascular risk as a priority. Simple prevention measures — vaccination, hygiene and clear communications — could substantially reduce preventable deaths.

Context and relevance

This piece reframes seasonal flu within the wider burden of chronic disease and makes the case that infectious and non-communicable diseases are interlinked. For policy-makers, clinicians and patients, the takeaway is practical: increasing vaccine uptake in at-risk groups is a low-cost, evidence-backed intervention that can lower both respiratory and cardiovascular mortality. The article is particularly pertinent during winter months when flu circulation and cardiac events both rise.

Why should I read this?

Short answer: because it kills the myth that the flu is ‘just sniffles’. Read this if you care about preventing avoidable heart attacks or want a sharper talking point for encouraging vaccination. We’ve done the slog — this article boils down why a jab is about more than sore throats; it can literally save hearts.

Source

Source: https://www.nature.com/articles/d41586-025-03598-0