Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study combines droplet-based single-nucleus RNA sequencing (snRNA-seq), single-cell whole‑genome sequencing (scWGS) and MERFISH spatial transcriptomics on prefrontal cortex…
Analog optical computer for AI inference and combinatorial optimization Summary The paper introduces the Analog Optical Computer (AOC), an all-analog opto-electronic platform designed to accelerate both AI inference (particularly iterative/fixed-point…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This study combines comparative embryology, genetics, optogenetics and live imaging across dipteran species to show that the transient cephalic furrow (CF)…
A brain-wide map of neural activity during complex behaviour Summary This paper from the International Brain Laboratory presents a publicly available, standardised, brain-wide electrophysiological dataset collected with 699 Neuropixels probe…
A prudent planetary limit for geologic carbon storage Summary This Nature paper maps global sedimentary basins and applies a series of precautionary exclusion layers (protected areas, polar regions, seismic hazard,…
DNA2 enables growth by restricting recombination-restarted replication Summary This Nature study shows that the conserved nuclease–helicase DNA2 is essential for eukaryotic cell proliferation because it suppresses recombination-restarted replication (HoRReR) at…
‘How is this possible?’ — two species birthed by one mother Quick summary A Nature report describes a striking discovery in Iberian harvester ants (Messor ibericus): queens produce male offspring…
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition Summary This study reveals a previously unknown, RNA-independent role for Cas9 in regulating CRISPR spacer acquisition. In Neisseria type II…
Inside a mosquito factory Summary A large production facility in Curitiba, Brazil, is rearing millions of mosquitoes each week with the expressed aim of reducing transmission of diseases such as…
What is classical computing? Summary Classical computing (also called binary computing) stores information as bits: 0 or 1. Modern processors such as x86 and ARM implement this model. Classical systems…
