Dynamic fibroblast–immune interactions shape recovery after brain injury Summary This study maps how central nervous system (CNS) fibroblasts and immune cells interact after brain injury (mouse models, marmoset stroke and…
A circuit that integrates drive state and social contact to gate mating Summary This Nature paper describes a neural circuit in male mice that gates the switch from appetitive (seeking)…
Multiple overlapping binding sites determine transcription factor occupancy Summary The authors present PADIT-seq, a high-throughput in vitro assay that measures transcription factor (TF) affinity to all possible ten-base-pair DNA sequences.…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This Nature paper reports a comparative, experimental and phylogenetic study showing that developing fly embryos evolved two different solutions to prevent…
Analog optical computer for AI inference and combinatorial optimisation Summary The paper presents the analog optical computer (AOC), an opto-electronic, fully analogue platform that runs iterative fixed-point searches to accelerate…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This Nature study uses single-nucleus RNA-seq (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics (MERFISH) to map transcriptional and…
DNA2 enables growth by restricting recombination-restarted replication Summary This study (Hudson et al., Nature, 2025) shows that the conserved nuclease-helicase DNA2 is essential because it restricts homologous-recombination-restarted replication (HoRReR) at…
A prudent planetary limit for geologic carbon storage Summary This Nature paper maps global sedimentary basins and applies a set of precautionary exclusion layers (protected areas, polar regions, seismic hazard…
A brain-wide map of neural activity during complex behaviour Summary This Nature paper from the International Brain Laboratory presents a public, brain-wide electrophysiological dataset collected with Neuropixels probes during a…
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition Summary This study reports a previously unknown, RNA-independent role for Cas9 in type II-C CRISPR systems: apoCas9 (Cas9 lacking bound…
