A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 Content summary This study reports a rare, prefusion-specific nanobody (Nb1_gbHSV) that neutralises both herpes simplex virus 1 and 2…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary DNA methylation is a central epigenetic mark that helps define cell identity, development and disease, but spatial mapping of…
A brain-wide map of neural activity during complex behaviour Summary This paper from the International Brain Laboratory presents a publicly available, brain‑wide electrophysiological dataset recorded with 699 Neuropixels probe insertions…
A way to determine how partial charges of atoms in a molecule are distributed Summary Researchers have demonstrated an experimental method that uses electron diffraction to determine how partial charges…
Depriving brain tumours of an amino acid could enhance chemotherapy Summary Glioblastoma — the most aggressive adult brain cancer with a five-year survival under 5% — shows a surprising metabolic…
The diversity of microbial enzymes that turn a pollutant into an inert gas Summary Reductase enzymes convert the potent greenhouse gas nitrous oxide (N2O) into harmless dinitrogen (N2). A new…
Cocaine-activated ion channels engineered to break the loop of addiction in rats Summary Researchers have designed ion channels that are selectively activated by cocaine and used these as chemogenetic tools…
Rewiring of cortical glucose metabolism fuels human brain cancer growth Summary This Nature paper uses clinical stable-isotope infusions in patients and matched intracranial patient-derived mouse models plus metabolic-flux modelling to…
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target Summary This Nature study used genome-scale genetic suppression screens (CRISPR and gene-trap) to identify ABHD18 as a robust genetic suppressor…
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia Summary This study uses allele-specific open-chromatin (ASoC) mapping in human iPSC-derived microglia (iMGs), astrocytes and neurons to identify functional non-coding…
