Visualizing lipid transport in cells
Visualising lipid transport in cells Summary This research briefing summarises a new Nature paper (Iglesias‑Artola et al.) that uses quantitative imaging to track how different lipid types move between membranes…
Anticancer compounds that exploit a compromised checkpoint in the cell cycle
Anticancer compounds that exploit a compromised checkpoint in the cell cycle Summary Many cancer-driving mutations disable the G1–S checkpoint that normally restrains entry into DNA replication, causing unchecked activity of…
Rare skeletal condition caused by enzyme’s failure to rescue a catalytic cycle
Rare skeletal condition caused by enzyme’s failure to rescue a catalytic cycle Summary Enzymes normally run repeatable catalytic cycles to drive metabolism. When a cycle stalls, specialised ‘rescue’ mechanisms restore…
Low-energy nuclear fusion boosted by electrochemistry
Low-energy nuclear fusion boosted by electrochemistry Summary Chen et al. report that electrochemical loading of deuterium into a metal target increases the rate of low-energy nuclear fusion when those trapped…
Could these five future agricultural innovations slow down climate change?
Could these five future agricultural innovations slow down climate change? Summary The article reviews innovations showcased at the F&A Next meeting in Wageningen that aim to make food production more…
Flat-panel laser displays through large-scale photonic integrated circuits
Flat-panel laser displays through large-scale photonic integrated circuits Summary This paper presents a new flat-panel laser-display architecture that replaces bulky free-space projector optics with a large-scale visible photonic integrated circuit…
Axonal injury is a targetable driver of glioblastoma progression
Summary Glioblastoma (GBM) is aggressive and largely incurable. This study shows that early tumour cells home to white matter (WM), cause axonal injury and trigger Wallerian degeneration (WD) — an…
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia Summary This Nature paper identifies the biochemical function of human TGDS and explains how its deficiency causes Catel–Manzke syndrome.…
Quantitative imaging of lipid transport in mammalian cells
Quantitative imaging of lipid transport in mammalian cells Summary This paper describes a new, quantitative pipeline that maps species-specific lipid transport and metabolism in mammalian cells with high spatiotemporal resolution.…
Discovery of a widespread chemical signalling pathway in the Bacteroidota
Discovery of a widespread chemical signalling pathway in the Bacteroidota Summary This Nature paper identifies and characterises a previously undescribed cell-density-dependent chemical signalling system in the phylum Bacteroidota (formerly Bacteroidetes).…