Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors Summary This Nature paper reports the design and preclinical characterisation of orally bioavailable macrocyclic peptides that block RxL-mediated substrate docking on cyclins…
mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity Summary This Nature paper identifies a protective gut–liver axis driven by muscarinic acetylcholine receptor 4 (mAChR4) expressed in intestinal goblet cells. The…
Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases Summary This study reports eight cryo-EM structures of mouse PMCA2 (with and without its accessory subunit neuroplastin) captured in multiple Post–Albers…
Proximity screening greatly enhances electronic quality of graphene Summary This Nature paper reports a device architecture that uses proximity screening — an atomically thin (3–4 layer, ≈1 nm) hBN spacer…
Fusion energy gets a boost from cold fusion chemistry Summary Researchers used an electrochemical technique to increase the rate of deuterium–deuterium fusion events in a desktop metal target. Inspired by…
Wyoming Launches First State-Backed Stablecoin on Seven Blockchains Summary The Wyoming Stable Token Commission has launched Frontier Stable Token (FRNT) on mainnet, issuing a state-backed, fiat-pegged stablecoin across seven blockchains.…
Anticancer compounds that exploit a compromised checkpoint in the cell cycle Key Points • Many cancer-driving mutations disable the G1–S checkpoint, causing unchecked activity of the E2F family of transcription…
Low-energy nuclear fusion boosted by electrochemistry Summary Electrochemistry can increase the rate of low-energy nuclear fusion by loading deuterium into a metal target and using an ion beam to induce…
Feeding bees with engineered yeast combats colony decline Summary Researchers have engineered yeast to produce rare but essential sterols normally found in pollen, creating a nutritionally complete food for honeybees…
Visualizing lipid transport in cells Summary Lipid molecules form the membranes that organise cellular biochemistry. This research briefing summarises Iglesias-Artola et al. (Nature), which presents quantitative imaging approaches that track…
