Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors Summary This Nature paper reports the discovery and preclinical validation of orally bioavailable, cell‑permeable macrocyclic peptides that block RxL‑mediated docking on cyclins…
Realisation of a doped quantum antiferromagnet in a Rydberg tweezer array Summary This Nature paper reports the experimental realisation of a doped quantum antiferromagnet using a programmable Rydberg tweezer array.…
Proximity screening greatly enhances electronic quality of graphene Summary This Nature paper demonstrates that placing graphene extremely close to an atomically flat metallic (graphite) gate with an ultrathin hBN spacer…
Experimental determination of partial charges with electron diffraction Summary This Nature paper introduces iSFAC modelling: an experimental refinement method that extracts absolute partial charges for every atom in a crystal…
Structural basis for the dynamic regulation of mTORC1 by amino acids Summary This paper reports high-resolution cryo-EM structures of the human GATOR2 nutrient‑sensing hub in complex with the leucine sensor…
Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases Summary This study reports eight high-resolution cryo-EM structures of mouse PMCA2 (with and without neuroplastin) captured across the Post–Albers cycle, combined…
Fusion energy gets a boost from cold fusion chemistry Summary Chemists report that electrochemical loading of deuterium into a palladium target raised fusion event rates in a desktop reactor. Inspired…
Immunotherapy using CAR T cells shows promising long-term outcomes for people with the blood cancer myeloma Summary The article reviews long-term clinical-trial data for a CAR T-cell therapy, ciltacabtagene autoleucel…
A baby benefits from personalised gene editing in the clinic Summary Scientists used base editing — a precise form of CRISPR-based genome editing — to correct a single pathogenic mutation…
Tiny flier could soar through the mesosphere powered only by light Summary Researchers report a lightweight, solar‑driven flying device that generates thrust in very low‑pressure air by exploiting thermal transpiration…
