NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers Summary This Nature paper reports the discovery and preclinical characterisation of selective small-molecule inhibitors of the histone methyltransferase NSD2 (notably…
High-accuracy laser spectroscopy of H2+ and the proton–electron mass ratio Summary The authors report Doppler-free, high-accuracy laser spectroscopy of a vibrational electric-quadrupole (E2) transition in the homonuclear molecular ion H2+.…
Summary The authors used cryo-electron microscopy, mass spectrometry and electrophysiology to define how fast N‑type inactivation occurs in the Shaker Kv channel. They show that an extended, predominantly non‑polar N‑terminal…
Summary This Nature study shows that excised signal circles (ESCs) — circular DNA by-products of V(D)J recombination — replicate and persist in normal B cells and in B cell precursor…
In situ light-field imaging of octopus locomotion reveals simplified control Summary This study used a novel light-field imaging system, EyeRIS, mounted on an ROV to record high-resolution, volumetric footage of…
Whole-genome sequencing of 490,640 UK Biobank participants Summary The UK Biobank completed high-coverage whole-genome sequencing (WGS) for 490,640 participants (mean coverage 32.5×), producing a deeply phenotyped, population-scale resource. The WGS…
Therapeutic genetic restoration through allogeneic brain microglia replacement Summary This paper reports a brain-restricted approach to replace microglia using allogeneic myeloid progenitor cells without the need for myeloablative conditioning. The…
Reply to: Inconclusive proof of ferroelectricity in peptide-VDF ribbons Summary This Matters Arising Reply (published 06 August 2025) is from Yang, Sai, Egner, Qiu, Palmer, Stupp and colleagues. It responds…
Inconclusive proof of ferroelectricity in peptide-VDF ribbons Summary This Matters Arising (Litterst, Butkevich & Kemerink) challenges the claim by Yang et al. that vinylidene fluoride (VDF) oligomers paired with tetrapeptides…
Monoclonal antibodies revolutionized biomedical science and health care Summary On 7 August 1975 Nature published Georges Köhler and César Milstein’s paper describing the hybridoma method for producing monoclonal antibodies. By…
