Summary This Nature paper introduces GRACE (Generative, Adaptive, Context-Aware 3D Printing), a workflow that fuses tomographic volumetric printing with light-sheet imaging, computer vision and parametric modelling so printers can scan…
Training of physical neural networks Summary This Nature review surveys the emerging field of physical neural networks (PNNs) — analogue hardware systems that perform neural-like computation using physical dynamics (optical,…
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 Summary This paper reports the discovery and structural characterisation of a prefusion‑specific nanobody (Nb1_gbHSV) that potently neutralises herpes simplex…
Brain-wide representations of prior information in mouse decision-making Summary This Nature paper from the International Brain Laboratory examines where and how prior information (the animal’s expectations about which side a…
Patterned invagination prevents mechanical instability during gastrulation Summary This paper investigates the developmental role and evolutionary origin of the cephalic furrow — a patterned epithelial invagination at the head–trunk boundary…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary This paper describes spatial-DMT, a new spatial multi-omics method that profiles the DNA methylome and the transcriptome simultaneously on…
A circuit that integrates drive state and social contact to gate mating Summary This paper identifies a thalamic gate that combines internal sexual drive with tactile contact to trigger consummatory…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study uses single-nucleus RNA sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics (MERFISH) on human prefrontal cortex…
Summary The paper introduces the Analog Optical Computer (AOC), an all-analog opto-electronic platform that unifies AI inference and combinatorial optimisation on the same hardware. The AOC runs a rapid fixed-point…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This study combines phylogenetic sampling, live imaging and targeted perturbations to show how early fly embryos avoid catastrophic mechanical collisions between…
