PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia Summary This Nature paper uses allele-specific open chromatin (ASoC) mapping in human iPSC-derived microglia (iMGs), astrocytes and neurons to identify…
Commensal yeast promotes Salmonella Typhimurium virulence Summary This Nature study shows that the common gut yeast Candida albicans can boost the virulence of Salmonella Typhimurium. Using in vitro co-cultures, cell…
Supervised learning in DNA neural networks Summary This paper reports a DNA-based neural network that can perform supervised learning in vitro. The authors design two new activatable seesaw-style DNA motifs…
3D-printed micro ion trap technology for quantum information applications Summary This Nature paper demonstrates a new fabrication route for trapped-ion hardware: high-resolution 3D printing (two-photon polymerisation, 2PP) of microscopic electrode…
Adaptive and context-aware volumetric printing Summary This paper introduces GRACE (Generative, Adaptive, Context-Aware 3D Printing), a workflow that equips volumetric 3D printers with the ability to image their build volume,…
Training of physical neural networks Summary This Nature review surveys the rapidly growing field of physical neural networks (PNNs) — analogue systems (optical, electronic, mechanical, etc.) that perform neural-like computation…
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 Content summary This study reports a rare, prefusion-specific nanobody (Nb1_gbHSV) that neutralises both herpes simplex virus 1 and 2…
Brain-wide representations of prior information in mouse decision-making Key Points • Mice learn and use a changing prior (block probability) to bias decisions and improve performance, especially on trials with…
Patterned invagination prevents mechanical instability during gastrulation Summary The study shows that the cephalic furrow — a patterned epithelial invagination at the head–trunk boundary in flies — acts as a…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary DNA methylation is a central epigenetic mark that helps define cell identity, development and disease, but spatial mapping of…
