A circuit that integrates drive state and social contact to gate mating Summary This study identifies a thalamic gating circuit that times the switch from appetitive to consummatory mating behaviour…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study combines single-nucleus RNA-sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics (MERFISH) to map transcriptional and somatic-genomic…
Analog optical computer for AI inference and combinatorial optimization Summary The paper presents the analog optical computer (AOC), an opto-electronic, fully analog platform that runs iterative fixed-point searches to accelerate…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This study maps the evolution and function of the cephalic furrow (CF) during early fly gastrulation. Combining phylogenetic sampling, live imaging,…
A brain-wide map of neural activity during complex behaviour Summary This paper from the International Brain Laboratory presents a publicly available, brain‑wide electrophysiological dataset recorded with 699 Neuropixels probe insertions…
A prudent planetary limit for geologic carbon storage Summary This Nature study produces a spatially explicit, precautionary estimate of how much CO2 can be stored safely in sedimentary basins worldwide…
DNA2 enables growth by restricting recombination-restarted replication Summary This Nature paper shows that DNA2 — a conserved nuclease/helicase — is essential because it prevents recombination-restarted replication (HoRReR) at stalled replication…
Two ant species, one mother Summary Nature reports that Iberian harvester-ant queens (Messor ibericus) can produce offspring that belong to two distinct species. The finding, described in a linked research…
Summary This study reports a previously unknown, guide-RNA-independent role for Cas9 in regulating spacer acquisition in type II CRISPR–Cas systems. The authors show that apoCas9 (Cas9 without bound crRNA/tracrRNA) stimulates…
AI spies questionable science journals, with some human help Summary A team of computer scientists from the University of Colorado Boulder, Syracuse University and the Eastern Institute of Technology trained…
