PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia Summary This Nature study uses allele-specific open-chromatin (ASoC) mapping in human iPSC-derived brain cells to pinpoint functional non-coding variants for…
Amygdala–liver signalling orchestrates glycaemic responses to stress Summary This Nature study identifies a previously undescribed neural axis from the medial amygdala (MeA) to the ventromedial hypothalamus (VMH) and onward to…
Supervised learning in DNA neural networks Summary This Nature paper reports an engineered DNA-based molecular system that performs supervised learning in vitro. The authors design and build a DNA strand-displacement…
Commensal yeast promotes Salmonella Typhimurium virulence Summary This Nature study shows that the common gut yeast Candida albicans can increase the virulence of Salmonella Typhimurium through a defined molecular interaction.…
Training of physical neural networks Summary Physical neural networks (PNNs) use analogue physical systems — optics, electronics, memristors, oscillators and other materials — to perform neural computations directly in hardware.…
Adaptive and context-aware volumetric printing Summary This paper introduces GRACE (Generative, Adaptive, Context-Aware 3D Printing), a workflow that combines tomographic volumetric printing with light-sheet imaging, computer vision and parametric modelling…
3D-printed micro ion trap technology for quantum information applications Summary This paper reports a new fabrication approach for trapped-ion quantum devices using high-resolution 3D printing (two-photon polymerisation) to create micro-scale…
Brain-wide representations of prior information in mouse decision-making Summary This study analysed large-scale electrophysiology (Neuropixels) and wide-field calcium imaging data from the International Brain Laboratory to ask where and how…
A nanobody specific to prefusion glycoprotein B neutralises HSV-1 and HSV-2 Summary This Nature paper reports the discovery and structural characterisation of a rare, prefusion-specific nanobody (Nb1_gbHSV) that neutralises both…
A circuit that integrates drive state and social contact to gate mating Summary This Nature study identifies a neural gate that times the switch from appetitive (approach, singing, investigation) to…
