Spatial joint profiling of DNA methylome and transcriptome in tissues Summary This paper describes spatial-DMT, a new spatial multi-omics method that jointly profiles the DNA methylome and the transcriptome on…
Patterned invagination prevents mechanical instability during gastrulation Summary This study combines live imaging, genetics, laser perturbations and a physical model to show that the cephalic furrow — a patterned epithelial…
Analog optical computer for AI inference and combinatorial optimisation Summary The paper introduces the analog optical computer (AOC), an all-analog, hybrid opto-electronic platform that runs iterative fixed-point searches for both…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study combines droplet-based single-nucleus RNA sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics (MERFISH) to map genomic…
DNA2 enables growth by restricting recombination-restarted replication Summary This paper shows that DNA2 — a conserved nuclease/helicase — is essential because it prevents excessive recombination-restarted replication (HoRReR) at stalled replication…
A prudent planetary limit for geologic carbon storage Summary This Nature paper provides a spatially explicit, precautionary estimate of how much CO2 can prudently be stored in sedimentary basins worldwide…
A brain-wide map of neural activity during complex behaviour Summary This paper from the International Brain Laboratory publishes a large, standardised, public dataset and initial analyses mapping single-neuron activity across…
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition Summary This study reports a previously unknown, RNA-independent role for Cas9 in regulating CRISPR spacer acquisition. Using Neisseria type II-C…
Latent resistance mechanisms of steel truss bridges after critical failures Summary This Nature paper reports an experimental and computational study that reveals how steel truss bridges redistribute loads after the…
Summary Cloudflare has confirmed that some customer data was exposed after attackers abused the Salesloft Drift compromise to access the company’s Salesforce support tenant. In a detailed post-mortem, Cloudflare’s security…
