Genetic suppression features ABHD18 as a Barth syndrome therapeutic target Summary This Nature study uses genome-wide genetic suppression screens (CRISPR and gene-trap) to identify ABHD18 as a modifier of TAFAZZIN…
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia Summary This Nature paper uses allele-specific open chromatin (ASoC) mapping in human iPSC-derived brain cells to functionally prioritise Alzheimer’s disease…
Infrastructure deficits and informal settlements in sub-Saharan Africa Summary This paper presents a continent-scale, block-level analysis of buildings, street access and population across sub‑Saharan Africa to quantify infrastructure deficits and…
Amygdala–liver signalling orchestrates glycaemic responses to stress Summary This Nature paper reports a previously unrecognised brain–liver circuit in mice that rapidly drives stress-related increases in blood glucose. The medial amygdala…
Supervised learning in DNA neural networks Content summary This paper reports a DNA-based molecular system that implements supervised learning and subsequent classification entirely in vitro. The authors design two new…
Commensal yeast promotes Salmonella Typhimurium virulence Summary This Nature paper reports a mechanistic, interkingdom interaction in the gut: the fungus Candida albicans can increase the virulence of Salmonella Typhimurium. Using…
Training of physical neural networks Summary This Nature review surveys the emerging field of physical neural networks (PNNs) — analogue, physics-based systems that perform neural-like computation. The authors assess current…
Adaptive and context-aware volumetric printing Summary This Nature paper introduces GRACE (Generative, Adaptive, Context-Aware 3D Printing), a workflow that merges tomographic volumetric printing with light-sheet imaging, computer vision and parametric…
3D-printed micro ion trap technology for quantum information applications Summary This Nature paper reports a practical route to fabricate micro ion traps by high-resolution 3D printing (two-photon polymerisation) followed by…
Patterned invagination prevents mechanical instability during gastrulation Summary This study integrates live imaging, genetics, laser perturbations and a particle–spring physical model to show that the cephalic furrow — a patterned…
