Brain-wide representations of prior information in mouse decision-making Summary This Nature paper from the International Brain Laboratory uses brain-wide electrophysiology (Neuropixels) and wide-field calcium imaging in mice performing a visual…
Summary This Nature paper reports the discovery and structural characterisation of a prefusion-specific camelid single-domain antibody (nanobody), named Nb1_gbHSV, that potently neutralises both herpes simplex virus 1 and 2 (HSV-1…
A circuit that integrates drive state and social contact to gate mating Summary This Nature paper identifies a neural circuit that gates the transition from appetitive to consummatory male mating…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary This paper introduces spatial‑DMT, a spatial multi‑omics method that simultaneously profiles the DNA methylome (mCG and mCH) and the…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This paper reports a comparative and functional study of a transient epithelial fold — the cephalic furrow (CF) — that forms…
Analog optical computer for AI inference and combinatorial optimisation Summary The paper introduces the analog optical computer (AOC), an all‑analogue, feedback‑based opto‑electronic platform built to accelerate both AI inference (particularly…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study uses single-nucleus RNA-sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics (MERFISH) on human prefrontal cortex (PFC)…
A prudent planetary limit for geologic carbon storage Summary This Nature paper maps global sedimentary basins and applies a precautionary set of exclusion layers (protected areas, polar regions, seismic hazard,…
A brain-wide map of neural activity during complex behaviour Summary This paper from the International Brain Laboratory presents a standardised, publicly released electrophysiological dataset that maps neural activity across nearly…
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition Summary This study (Zhou et al., Nature, 2025) reveals a previously unrecognised role for Cas9 that is independent of its…
