A circuit that integrates drive state and social contact to gate mating Summary This paper identifies a thalamic gate that combines internal sexual drive with tactile contact to trigger consummatory…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary This paper describes spatial-DMT, a new spatial multi-omics method that profiles the DNA methylome and the transcriptome simultaneously on…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This study combines phylogenetic sampling, live imaging and targeted perturbations to show how early fly embryos avoid catastrophic mechanical collisions between…
Summary The paper introduces the Analog Optical Computer (AOC), an all-analog opto-electronic platform that unifies AI inference and combinatorial optimisation on the same hardware. The AOC runs a rapid fixed-point…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study uses single-nucleus RNA sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics (MERFISH) on human prefrontal cortex…
A prudent planetary limit for geologic carbon storage Summary This Nature paper provides a spatially explicit, precautionary assessment of how much CO2 can prudently be stored in sedimentary basins worldwide…
A brain-wide map of neural activity during complex behaviour Summary This paper from the International Brain Laboratory presents a large, standardised electrophysiological dataset and initial analyses mapping single-neuron activity across…
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition Summary This Nature paper reports that Cas9 has a previously unrecognised, RNA-independent role in controlling CRISPR spacer acquisition. The authors…
Inside a mosquito factory Summary A large facility in Curitiba, Brazil, is producing mosquitoes by the million with the aim of reducing transmission of dengue, Zika and chikungunya. The site…
DNA2 enables growth by restricting recombination-restarted replication Summary This Nature paper shows that the conserved nuclease/helicase DNA2 (Dna2 in yeast) is essential because it processes stalled replication forks to prevent…
