Genetic suppression features ABHD18 as a Barth syndrome therapeutic target Summary This Nature study used genome-wide genetic suppression screens in TAFAZZIN (TAZ)‑deficient human cells to identify modifiers of Barth syndrome…
One mother for two species via obligate cross-species cloning in ants Summary This Nature paper describes a previously unknown reproductive system in the harvester ant Messor ibericus. Using population genomics,…
Dynamic fibroblast–immune interactions shape recovery after brain injury Summary This Nature paper maps how central nervous system (CNS) fibroblasts respond to focal brain injury and how they interact with immune…
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia Summary This Nature paper uses allele-specific open chromatin (ASoC) mapping in human iPSC-derived microglia (iMGs), astrocytes and neurons to identify…
Amygdala–liver signalling orchestrates glycaemic responses to stress Summary This Nature study identifies a previously unrecognised neural axis from the medial amygdala (MeA) through the ventromedial hypothalamus (VMH) to the liver…
Multiple overlapping binding sites determine transcription factor occupancy Summary The authors introduce PADIT-seq, an in vitro transcription-based sequencing assay that measures transcription factor (TF) affinity to every possible 10-base-pair DNA…
Supervised learning in DNA neural networks Summary This paper reports a DNA-based neural network that can perform supervised learning in vitro. The authors design two new activatable seesaw-style DNA motifs…
Commensal yeast promotes Salmonella Typhimurium virulence Summary This Nature study shows that the common gut yeast Candida albicans can boost the virulence of Salmonella Typhimurium. Using in vitro co-cultures, cell…
Training of physical neural networks Summary This Nature review surveys the rapidly growing field of physical neural networks (PNNs) — analogue systems (optical, electronic, mechanical, etc.) that perform neural-like computation…
Adaptive and context-aware volumetric printing Summary This paper introduces GRACE (Generative, Adaptive, Context-Aware 3D Printing), a workflow that equips volumetric 3D printers with the ability to image their build volume,…
