3D-printed micro ion trap technology for quantum information applications Summary This Nature paper demonstrates a new fabrication route for trapped-ion hardware: high-resolution 3D printing (two-photon polymerisation, 2PP) of microscopic electrode…
Patterned invagination prevents mechanical instability during gastrulation Summary The study shows that the cephalic furrow — a patterned epithelial invagination at the head–trunk boundary in flies — acts as a…
Brain-wide representations of prior information in mouse decision-making Key Points • Mice learn and use a changing prior (block probability) to bias decisions and improve performance, especially on trials with…
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 Content summary This study reports a rare, prefusion-specific nanobody (Nb1_gbHSV) that neutralises both herpes simplex virus 1 and 2…
Single-cell transcriptomic and genomic changes in the ageing human brain Summary This study combines single-nucleus RNA-sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics (MERFISH) to map transcriptional and somatic-genomic…
A circuit that integrates drive state and social contact to gate mating Summary This study identifies a thalamic gating circuit that times the switch from appetitive to consummatory mating behaviour…
Spatial joint profiling of DNA methylome and transcriptome in tissues Summary DNA methylation is a central epigenetic mark that helps define cell identity, development and disease, but spatial mapping of…
Divergent evolutionary strategies pre-empt tissue collision in gastrulation Summary This study maps the evolution and function of the cephalic furrow (CF) during early fly gastrulation. Combining phylogenetic sampling, live imaging,…
Analog optical computer for AI inference and combinatorial optimization Summary The paper presents the analog optical computer (AOC), an opto-electronic, fully analog platform that runs iterative fixed-point searches to accelerate…
DNA2 enables growth by restricting recombination-restarted replication Summary This Nature paper shows that DNA2 — a conserved nuclease/helicase — is essential because it prevents recombination-restarted replication (HoRReR) at stalled replication…
